University of Nottingham

University of Nottingham

Stem Cells, Tissue Engineering and Modelling (STEM)

The Stem Cell Biology Group comprises 4 academics who are part of the inter-school Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM); Professor Lorraine Young's (Director of STEM) laboratory studies the epigenetic changes that occur in sperm and oocytes to reprogramme gametes into a functional embryonic nucleus and also the epigenetic changes induced when a somatic cell is introduced into an oocyte during somatic cell nuclear transfer; Dr. Chris Denning's (Associate Professor) group has generated standardised and simplified conditions for the culture of human embryonic stem cells; this has enabled the efficiency of induction of these cells towards cardiomyocytes to be considerably increased; the group is using the derived cardiomyocytes to provide novel in vitro systems for drug screening and toxicology, as well as to provide insights into poorly understood genetic disorders that affect the human heart, such as Duchenne muscular dystrophy. Dr Tufarelli (Lecturer) studies the role of DNA methylation regulatory mechanisms involved in the pluripotency and differentiation of embryonic stem cells and in cancer stem cells. Dr Virginie Sottile's (Lecturer) group is interested in the differentiation potential of adult stem cells, from both bone marrow and brain origin; the lab investigates the differentiation of mesenchymal and neural stem cells in comparison to pluripotent stem cells; the group uses stem cell isolation, in vitro culture, gene expression analysis and transplantation models to investigate the mechanisms governing cell fate decisions in stem cells, and evaluate their potential use for tissue repair.

Entry requirements

Applicants for PhD programmes are generally required to hold an Honours degree at 2.1 level or above (or international equivalent) in an appropriate subject; candidates are generally required to submit a research proposal with their applications; International English Language Testing System (IELTS) [Academic version] 6.0 with no less than 5 in any one element; Test of English as a Foreign Language (TOEFL): Paper version:550 with a minimum of 4.0 in the Test of Written English (TWE); Internet-based version: 79 with no less than 17 in any one element.


Qualification Study mode Start month Fee Course duration
PhD Full-time £ 3,980 per Academic year (home fees) 3 years
PhD Part-time - 6 years

Campus details

Campus name Town Postcode Region Main campus Campus Partner
University Park Campus Nottingham NG7 2RJ East Midlands

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Key information

Postgraduate Enquiry Team
Telephone number: 
0115 951 5559